Library Preparation

Improved efficiency at every step

TOMA’s proprietary chemistry and methods minimize sample loss and biases — maximizing the quality and yield of DNA sequencing data. Our simple, highly efficient, single-stranded library preparation techniques differentiate us from our competition.

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Our DNA library preparation method:

  1. Excises damaged DNA from the sample to minimize errors and distortions common to repair-based methods.
  2. Uses single-stranded, highly efficient adaptor ligation, adding small pieces of DNA or oligos to the sample to allow sequencers to read the sample DNA. TOMA adaptor ligation processes both single- and double-stranded DNA.
  3. Efficiently captures gene targets from the sample, using a Stanford invention called oligo selective sequencing (OS-Seq) — reducing the capture step to two hours and library preparation is down to a single day.

TOMA scientists have built user-friendly genetic assays that contain all of the necessary reagents and step-by-step directions to prepare sample DNA for sequencing.

The powerful OS-Seq method can be customized to target any genes of interest during the capture step. Laboratories can run a standard panel of 130 clinically actionable cancer genes, such as genes associated with approved therapies and clinical trials. Or they can order a custom set of genes for analysis.

TOMA OS-SeqTM Technology — Versatile & Customizable

 
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