SIGNOMETM Tumor Profiling System

Comprehensive Detection of Cancer Somatic Variants

The SIGNOMETM Tumor Profiling System is a complete, comprehensive solution for somatic variant detection in cancer. The system includes a complete set of reagents to enable the wet laboratory chemistry, coupled with a comprehensive data analysis to produce detailed analysis and reports.

Laboratories can use the SIGNOMETM Tumor Profiling System to accurately detect and analyze all alterations in single – and double – stranded DNA from low volume and poor quality tumor tissue.

In addition to its standard panel of 130 cancer genes, SIGNOME can be customized to analyze any genes of interest.

The SIGNOMETM Tumor Profiling System

Using COMPASSTM, scientists have everything at their fingertips to identify significant alterations from precious tumor FFPE samples using less material while producing the highest quality data.

LIBRARY
PREPARATION
MODULE I

complete set of reagents to prepare extracted dna for sequencing

LIBRARY
PREPARATION
MODULE II

gene specific content powered by Oligo Selective Sequencing or OS-SeqTM

DNA STANDARDS
& CONTROL
MODULE

standards ensure “ground truth” variant detection

STRATUSTM
ANALYSIS
MODULE

cloud based uploading and analysis tool

CLINICAL ANNOTATION
&
REPORTING MODULES

identify therapeutic options

MOLECULAR
TUMOR BOARD
MODULE

provide clinical interpretation of results

TOMA OS-SEQTM 130 CANCER GENE PANEL

For Research Use Only. Not for use in diagnostic procedures.

+ 130 Gene Cancer Panel
+ Breast Cancer Genes
+ Lung Cancer Genes
+ Ovarian Cancer Genes

The TOMA SIGNOMETM Tumor Profiling System is a highly efficient comprehensive solution to generate rich tumor profiling data.

Powered by TOMA OS-SeqTM, the target enrichment is complete in less than two hours to enable detection of variants down to a 2% variant allele frequency (VAF).

SIGNOMETM offers a fast, simple approach to generating reliable sequencing data.

TOMA’s cloud based data analysis tools:

Simple - Complete - Meaningful

STRATUS

Upload
Authenticate
Encrypted Transport
Encryption at Rest
Start Workflow

SIGNOMETM

Analyze
Proprietary Algorithms
Map Reads
Identify & Score Variants, CNAs
Output: Interpretable Somatic Alternations

SEQUENCING PERFORMANCE METRICS

6 CONCURRENT SAMPLES ON ILLUMINA MISEQ